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Rabbit Anti-TLR4

价格：电议

采购度：809 原产地：其它

发布时间：2018/6/25 11:04:13

Rabbit Anti-TLR4 Six human homologs of the Drosophila Toll receptor were initially identified based on their sequence similarities and designated toll-like receptors (TLR).

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标签：Rabbit Anti-TLR4

详细信息

Rabbit Anti-TLR4
Background: Six human homologs of the Drosophila Toll receptor were initially identified based on their sequence similarities ａnd designated toll-like receptors (TLR).
Toll receptors are involved in mediating dorsoventral polarization in the developing Drosophila embryo ａnd also participate in the host immunity. The TLR family of proteins are characterized by a highly conserved Toll homology (TH) domain, which is essential for Toll-induced signal transduction. TLR1, as well as the other TLR family members, are type I transmembrane receptors that characteristically contain an extracellular domain consisting of several leucine-rich regions along with a single cytoplasmic Toll/IL-1R-like domain. TLR2 ａnd TLR4 are activated in response to lipopolysacchride (LPS) stimulation, which results in the activation ａnd translocation of NFκB ａnd suggests that these receptors are involved in mediating inflammatory responses. Expression of TLR receptors is highest in peripheral blood leukocytes, macrophages ａnd monocytes. TLR6 is highly homologous to TLR1, sharing greater
than 65% sequence identity; like other members of TLR family, it induces NFκB signaling upon activation.

specificity :
–Anti- TLR4 is a rabbit polyclonal antibody raised against amino acids 339-638 mapping within an N-terminal extracellular domain of TLR4
–specific for TLR4 of human, mouse ａnd rat,pig,cow,chicken
–use for western blotting,elisa,immunoprecipitation ａnd immunohistochemistry
–Protein G affinity chromatography purification, purity :>95%
–Isotype: IgG
–mol wt: 95 kDa

Application :
–Western blotting 1:100-500
–Immunohistochemistry 1:100-500
–ELISA 1:500-1000
–Optimal working dilutions must be determined by the end user.
Storage: Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody, the antibody is stable for at least six weeks at 2-4 ℃
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

更新时间：2024/10/21 9:45:00

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